Rapid diagnosis of sepsis using biomarker signatures

نویسنده

  • Nigel James Silman
چکیده

Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which when measured in combination have high predictive values, offers a paradigm shift forwards for rapid, near-patient diagnosis. These analyses more closely mirror the rapid blood chemistry and hematology analyses which often are used for near-patient testing and diagnosis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker

Abstract Background and objectives: cardiac surgery is often associated with acute kidney injury (AKI). Nowadays, AKI is typically diagnosed by an increase in serum creatinine, which is a delayed and unreliable biomarker. Recent studies recommended using the liver type fatty acid binding protein (L-FABP) as an early biomarker. Material and Methods: The urine samples of 18 adult patients undergo...

متن کامل

Diagnosis of bacteremia in patients with suspected septicemia using polymerase chain reaction method

Background: Sepsis or blood stream infection is a clinical lethal syndrome with severe systemic inflammatory response to infection, if not treated quickly, is associated with dangerous consequences and high morbidity and mortality. The traditional and conventional method for identification of sepsis is blood culture method which is so time-consuming and long that it eliminates the possibility o...

متن کامل

Diagnosis of Sepsis in Children Using the BACTEC Method

Background and purpose: Sepsis is a bacterial infection. Many patients lose their lives due to delayed diagnosis. The BACTEC method could be used for rapid and precise diagnosis of sepsis which can isolate different organisms in the shortest time with maximum sensitivity. This study aimed to identify the prevalence of positive blood cultures using the BACTEC in children with sepsis and to deter...

متن کامل

Hematological and Biological Markers of Neonatal Sepsis

  Septicemia in neonates is the commonest cause of mortality. Early recognition and diagnosis of neonatal sepsis remains a challenge because of the variable and nonspecific clinical presentation. The laboratory criteria are often non specific and not fully reliable. The objective of this review is to highlight the various hematological and biological markers of neonatal sepsis. We searched ...

متن کامل

Neonatal Sepsis: An Update

Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2013